Slin Sane, Insulin supplement, Insulin, Insulin carbohydrates

SLIN SANE (LIMITED TIME 21.95 NEW AND IMPROVED)

Physique athletes have long since realized the profound benefits of the anabolic hormone insulin, whether it be through maximizing endogenous timing and release or simply by injecting the exogenous compound. Insulin release is stimulated in the body simply by the ingestion of carbohydrates, certain amino acids, or the combination of both. However, many people have inherent dysfunction in the complex insulin signaling cascade, which can result in limited nutrient uptake by the muscle cells, excessive uptake by the fat cells, too much insulin released, or too little insulin released. Even those with proper nutrient signaling can still greatly benefit their quest for increased muscle gain and accelerated fat loss by optimizing the body’s nutrient storage capabilities.

Slin-Sane was designed to be just that nutrient storage optimization tool, by working to maximize uptake of glucose and amino acids at the muscle cell through multiple angles similar to and in conjunction with insulin, while delivering increased vascularity and muscle fullness.

Overview of ingredients and function

Lagerstroemia Speciosa

A small to medium sized tree grown throughout parts of southern Asia, the leaves of Lagerstroemia Speciosa (LS) yield a novel compound called Banaba. Commonly used in Phillipine folk medicine to treat symptoms of diabetes, this compound shows great promise for its multi-faceted beneficial interaction with glucose and insulin.
Initially, researchers thought banaba’s positive effects to be solely related to its content of corosolic acid, but studies have since shown there may be multiple other compounds in the leaf that contribute to its numerous benefits.
Multiple studies have shown LS to have the ability to increase translocation of the GLUT4 receptor at the muscle cell, therefore allowing increased nutrient uptake (1,9). This cellular receptor is the main gatekeeper for nutrient influx, and optimal expression can greatly enhance cellular storage capabilities, increasing muscle fullness.

A recent study out of Japan found a significant reduction in blood glucose response after feeding sugar to subjects pretreated with LS versus subjects who didn’t take the supplement (2). A similar study published in Diabetes Research and Clinical Practice also showed a potent glucose lowering effect over control from ingestion of 75g of glucose after administration of LS (6). In addition to reduction in glucose response to food intake, LS has been shown in multiple studies to lower fasting glucose and insulin levels, a key marker in overall health and cell responsiveness to nutrient sensing (3,8,10,13).
Aside from Lagerstroemia’s basic glucose stabilizing effects, it touts numerous other capabilities related to health and longevity including elevating insulin sensitivity (8), lowering free fatty acids, blood pressure, CRP, and oxidative stress (7), suppression of adipocyte differentiation similar to AICAR (5), reducing triglycerides and A1C levels (8), and significantly lowering hepatic lipid content (11).

Looking at things purely from a body composition angle, LS can help promote the anabolic effects of insulin by mimicking the hormone and working through an independent mechanism of insulin itself (12), act anti-catabolically to prevent muscle breakdown (4), lower fasting glucose/insulin levels, and increaseinsulin sensitivity to aid in fat loss and muscle gain.

Lagerstroemia Review
Enhances glucose uptake at muscle cell
Reduces fat gain from a high fat diet
Lowers blood glucose response to feeding
Reduces fasting glucose, insulin, triglycerides, FFA’s, CRP and A1C
Increases insulin sensitivity and GLUT4 translocation
Increases adiponectin

Gymnema Sylvestre
Used as a natural treatment for diabetic symptoms in parts of India for thousands of years, this tropical herb has many promising attributes for the modern day physique enthusiast. Much of the research on this compound has focused on diabetic conditions, with some pretty incredible results.
Studies have shown Gymnema to reverse elevated cholesterol and triglycerides (15,17,26), decrease serum blood glucose in a fasted and fed state (16,20,22,24,26), and improve the time it takes to clear glucose from the bloodstream post-prandially (24). A long term study out of India looked at diabetics who had been given Gymnema daily for up to a year, and found that fasting glucose levels had dropped from an average of 232 mg/dL to a remarkable 152 mg/dL, with no change in the control group. The Gymnema group was able to halve their required insulin dosages over the course of the study, and they also showed a significant drop in A1C levels (22), which was later confirmed by a 2009 study in the journal Phytomedicine (26).

Gymnema has a profound effect on the insulin secreting cells of the pancreas, known as the beta cells located inside the islets of Langerhans. The herb has the unique ability to stimulate insulin release, even without the presence of carbs (18), and can actually regenerate the beta cells that often become damaged and dysfunctioning over time (22). One study published in the Journal of Ethnopharmacology even found Gymnema to double the number of beta and islet cells in diabetic rats (23).
Aside from the profound effects on pancreatic function, Gymnema also acts at nutrient destination cells by increasing permeability of cell walls, which assists in the process of nutrient uptake (18). Damaged cell walls become less permeable over time, due to excess insulin in the bloodstream and dietary deficiencies, among other things. Gymnema acts as sort of a cellular repair kit, restoring optimal function.

The addition of Gymnema alongside Lagerstroemia to Slin-Sane allows for a two-pronged attack for optimization of glucose and insulin. By increasing the enzymes responsible for glucose utilization (25), enhancing the action of endogenous insulin (22), stimulating insulin release and repairing beta cells, increasing cell permeability and repairing insulin induced damage to the liver, kidney and muscle cells (25), Gymnema will aid in driving nutrients into the muscles for a full, pumped feeling and increased performance.

Gymnema Review
Stimulates insulin release and mimicks insulin
Increases nutrient uptake
Increases cell permeability
Reduces serum glucose, cholesterol, triglycerides, and A1C
Elevates HDL levels
Regenerates pancreatic cells

L-Norvaline
An analogue of the branched chain amino acid L-Valine, this compound was chosen due to its vasodilating properties for an increase vascularity, muscle pump, and nutrient delivery.

L-Norvaline works by inhibiting the arginase enzyme, which is responsible for the breakdown of L-Arginine into L-Ornithine and urea (28-30). An animal study published in the American Journal of Heart and Circulatory Physiology found that L-Norvaline increased Nitric Oxide production by 55% (28).

L-Norvaline Review

Increases Nitric Oxide production
Causes vasodilation and muscle pump

Slin-Sane Overview

Enhances vasodilation and muscle pumps
Elevates nitric oxide
Drives nutrients into cells
Stimulates insulin release, mimicks insulin and enhances insulin’s endogenous effect
Reduces fasting glucose and insulin
Reduces glucose response to meals
Reduces fat gain and speeds up fat loss
Regenerates pancreatic beta cells
Supports healthy blood lipids
Lowers liver lipid content (major factor in cardiovascular disease)
Increases plasma adiponectin

1. When should I take Slin-Sane, and do I need to cycle it?

Slin-Sane should be taken before carbohydrate heavy meals (30g or more). Take 1 capsule about 15 minutes before you start eating. If you’re using it every day, you may want to take a couple of weeks off after a month of use as its generally a good idea to cycle any supplement, although studies have used the ingredients for long durations with no ill effects.

2. How do I use Slin-Sane for a muscle building phase?

You should be able to increase your carbohydrate intake higher than a normal “bulking” phase with the use of Slin-Sane, due to its favorable nutrient partitioning effects you won’t have to worry about excess fat gain. Take 1 capsule before 3 carbohydrate heavy meals and up your carbs by about 20-30% above intake for normal muscle building phases. Be sure to take a serving before your workouts, and sip on a fast absorbing carb+protein shake while training. You should notice a significant increase in pump and vascularity during the workout, and noticeably
faster muscle gain over the course of usage.

3. How do I use Slin-Sane for a fat loss phase?

Again you should be able to lose fat on a slightly higher carb intake than normal, but you’ll want to cut your carb intake down significantly from a muscle building phase. You can try timing most of your daily carbs around weight training (a shake during the workout and one carb heavy meal after), and take a serving of Slin-Sane before each. You can also spread your carbs out into three meals throughout the day with a serving of Slin-Sane before each. You should notice accelerated fat loss over the course of usage.

4. Can I take Slin-Sane without carbs?

This is not recommended due to its hypoglycemic effects; however certain advanced users may want to experiment with Slin-Sane before meals on a very low carbohydrate or ketogenic diet. Just be sure to have some carbs around in case hypoglycemia starts to sneak up on you, as it can be fairly uncomfortable.

5. Can females use Slin-Sane?

Absolutely. Slin-Sane works the same way in women as it does in men, and none of the ingredients exhibit any sort of gender specific effect.

6. Slin-Sane safe to stack with other supplements?

Definitely. Slin-Sane is safe with most other supplements, just watch out for anything that is known to lower blood glucose or increase insulin sensitivity. You should avoid any of the various forms of Alpha Lipoic Acid at the same meal as Slin-Sane, and you may want to time fish oil with meals away from the Slin-Sane, or use a lower dose than normal at the same meal.



References
1. Shi L, Zhang W, Zhou YY, Zhang YN, Li JY, Hu LH, Li J. 2008. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. Eur J Pharmaco. 584(1):21-9.
2. Takagi S, Miura T, Ishibashi C, Kawata T, Ishihara E, Gu Y, Ishida T. 2008. Effect of corosolic acid on the hydrolysis of disaccharides. J Nutr Sci Vitaminol (Tokyo). 54(3):266-8.
3. Yamada K, Hosokawa M, Yamada C, Watanabe R, Fujimoto S, Fujiwara H, Kunitomo M, Miura T, Kaneko T, Tsuda K, Seino Y, Inagaki N. 2008. Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice. Biol Pharm Bull. 31(4):651-5.
4. Yamada K, Hosokawa M, Fujimoto S, Fujiwara H, Fujita Y, Harada N, Yamada C, Fukushima M, Ueda N, Kaneko T, Matsuyama F, Yamada Y, Seino Y, Inagaki N. 2008. Effect of corosolic acid on gluconeogenesis in rat liver. Diabetes Res Clin Pract. 80(1):48-55.
5. Zong W, Zhao G. 2007. Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes. Asia Pac J Clin Nutr. 16 Suppl 1:346-52.
6. Fukushima M, Matsuyama F, Ueda N, Egawa K, Takemoto J, Kajimoto Y, Yonaha N, Miura T, Kaneko T, Nishi Y, Mitsui R, Fujita Y, Yamada Y, Seino Y. 2006. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res Clin Pract. 73(2):174-7.
7. Yamaguchi Y, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M. 2006. Corosolic acid prevents oxidative stress, inflammation and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome. Life Sci. 79(26):2474-9.
8.Park MY, Lee KS, Sung MK. 2005. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life Sci. 77(26):3344-54.
9.Miura T, Itoh Y, Kaneko T, Ueda N, Ishida T, Fukushima M, Matsuyama F, Seino Y. 2004. Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice. Biol Pharm Bull. 27(7):1103-5.
10. Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater R. 2003. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol. 87(1):115-7.
11. Suzuki Y, Unno T, U****ani M, Hayashi K, Kakuda T. 1999. Antiobesity activity of extracts from Lagerstroemia speciosa L. leaves on female KK-Ay mice. J Nutr Sci Vitaminol (Tokyo). 45(6):791-5.
12. Hattori K, Sukenobu N, Sasaki T, Takasuga S, Hayashi T, Kasai R, Yamasaki K, Hazeki O. Activation of insulin receptors by lagerstroemin. J Pharmacol Sci. 2003 Sep;93(1):69-73.
13. Liu F, Kim J, Li Y, Liu X, Li J, Chen X. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells. J Nutr. 2001 Sep;131(9):2242-7.
14. Ramkumar KM, Manjula C, Sankar L, Suriyanarayanan S, Rajaguru P. 2009. Potential in vitro antioxidant and protective effects of Gymnema montanum H. on alloxan-induced oxidative damage in pancreatic beta-cells, HIT-T15. Food Chem Toxicol. 47(9):2246-56.
15. Ramkumar KM, Vijayakumar RS, Ponmanickam P, Velayuthaprabhu S, Archunan G, Rajaguru P. 2008. Antihyperlipidaemic effect of Gymnema montanum: a study on lipid profile and fatty acid composition in experimental diabetes. Basic Clin Pharmacol Toxicol. 103(6):538-45.
16. Gholap S, Kar A. 2003. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie. 58(6):413-5.
17. Shigematsu N, Asano R, Shimosaka M, Okazaki M. 2001. Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats. Biol Pharm Bull. 24(6):713-7.
18. Persaud SJ, Al-Majed H, Raman A, Jones PM. 1999. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol. 163(2):207-12.